The path to infinite energy and youthfulness

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Hi

here is my experimental, fragmented, and unfinished approach to building an advanced pharmacological stack. I will try to update and comment on it continuously. Need feedback.

Some notes beforehand:

  • This selection of substances should prioritize strong modulators that provide meaningful effects for ones life.
  • Main intention in all pharmacological experiments is that the resulting effects and side effects must always be life-affirming, life-enhancing, and somehow beneficial to life. Corrections must be made for every undesirable effect.
  • A strong foundation of health and stability is a prerequisite for experimentation, ensuring safety and effectiveness.
  • All of this work in progress, i am trying to not attach myself to those and I will throw them overboard if they don’t give me what I had hoped for
  • My risk management allows me also to quickly bounce back from failures
  • Absolute beginner-level substances are forbidden; every substance should be a strong modulator on its own. It should allow me to reach the next level.
  • Route of Administration is irrelevant. All needed materials for preparation are available, like millimeter scales, gloves, sterile material, carrier substances, test kits, etc.
  • Logistics, finances, and legal considerations should not act as limiting factors in experimentation.
  • This approach should be phenomenological rather than reductionist or biomarker-dependent. These substances should be embodied, experienced, felt, and involved in everyday life, shaping and structuring it.
  • I don’t care about impersonal universal guidelines, reference values, or standardized norms, which are designed for the masses.
  • These substances should not antagonize each other but should be additive and work synergistically.
  • Ranking regarding modulation:
    PAM > SAM > Biased Agonist > Partial Agonist > NAM > Full Agonist > Super Agonist > Inverse Agonist > Competitive Antagonist > Non-Competitive Antagonist
    (and vice also vice versa if opposite effect is intendend)
  • Main health markers (needs refinement and thought):
    Wakefulness, Infinite Energy, Childhood Remembrance, Childlikeness, Dream Potentiation, Libido, Perceptual Sharpness, Creativity, Playfulness, Sociability, Lightness of Being (mind and body)

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List of targets and substances
Alpha1-adrenergic receptor antagonist- Doxazosin

Alpha2-adrenergic receptor antagonist (day) - Yohimbine
Alpha2-adrenergic receptor agonist (night) - Guanfacine, Clonidine

Beta1,2-adrenergic receptor antagonist (night) - Propranolol
Beta2-adrenergic receptor agonist - Clenbuterol

Adenosine A2A receptor antagonist (day) - Caffeine, KW-6356

cAMP increase - Forskolin, Yohimbine, Caffeine

Pde5-inhibitor - Sildenafil, Tadalafil

AR agonist - Methandienone, Masterolone

D Modulation (DAT Inhibition & D Synthesis) - Bromantane

D1 PAM - ASP-4345
D1 agonist - Sulbutiamine

D2 PAM - MIF-1
D2 agonist (+Prolactine Inhibtion) - Metergoline[2], Cabergoline, Pramipexol
D2 autoreceptor Antagonist - Amisulpride (low dose)

D3 PAM?
D3 agonist - Forskolin, Pramipexol

D4 PAM - MIF-1

Monoamine Transporter Inhibition (DRI + NET + SERT) - Tesofensine

5-HT1A antagonism - Spiroxatrine[1], WAY 100635[1], Metergoline
5-HT1B antagonism - Yohimbine, Metergoline
5-HT1D agonist - Metergoline

5-HT2A agonism? - 2c-b (partial, full? even antagonistic?)
5-HT2A antagonism? - Metergoline

5-HT2B antagonism - Yohimbine

5-HT2C agonism?antagonism? - 2c-b
5-HT2C antagonism? - Metergoline

5-HT3A antagonism (needed?) - Tropisteron, Ondansetron, Mirtazapine

5-HT4A agonism - Usmarapride

5-HT6A antagonism - Rugosa Rose Flower Extract

AMPA PAM - Piracetam, TAK-653

NMDA PAM - Neboglamine
NMDA agonist - D-Aspartic Acid (?)

NMDA receptor antagonist - Ketamine (use case)

Acetylcholesterinase inhibition - Donepezil, Galantamine
a7 nAChR modulator - Tropisteron, Galantamine

M1 receptor PAM - VU319[1]

Trk A,B,C PAM - ACD856

MAO-B Inhibitor - Rasagiline, Selegeline, Safinamide

MAO-A Inhibitor - Moclobemide

H1 receptor agonist - L-Histidine (oder directly stimulates Histamine H2-receptors ?)

H2 Receptor ?

H3 receptor antagonist - Pitolisant, Kutaja bark (Conessine), Betahistine (weak), Ciproxifan

H4 receptor antagonist - Thioperamide
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Other:
Thyroid modulation - T3, T4

Empathy & Sexuality modulation - 5-mapb, 6-apb

General Peptides - Erythropoietin

Uncategorized - 2-fma, Modafinil

Nutrient Density

  • Mushroom mix (only those which are considered fountain of life in different civilizations)
  • Dessiccated Oyster
  • Dessiccated Organs (primary not domesticated animals)

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[1] Not available yet
[2] Even though metergoline have many beneficial targets, it may interfere with 2c-b, which is far more important
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5 Likes
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Wow! Thank you! I also enjoy ketamine on occasion. I do THC/CBD/Chocolate edibles, Coffee with MCT powder, AG1 and lots of green tea with a whole hoard of supplments at night. :stuck_out_tongue:

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Wow that is a well thought out list

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Very cool post, one of the higher quality ones I’ve seen. :slightly_smiling_face:

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Some more details and answered questions from a crosspost:

“That’s a lot of neurotransmitter modulation. Are you taking these all at once? Or something else? Also, your general framework is fairly flawed in terms of grouping by receptor type, every receptor is expressed in different concentrations in different areas of the body, and interventions can be selective or non-selective. If you’re trying to be systematic about experimentation in this way, you’d need to be more specific about which targets and where you’re actually interacting with. This is especially true for neurotransmitter targets.”

The modulation of the mentioned targets has the most significant downstream impact. The effects are real and not just appealing on paper. It took considerable time to filter these, but I believe I have listed almost all the important ones.

Furthermore, the list contains backup targets and molecules in case one does not work as intended. For example, D1 agonism serves as a backup for D1 PAM.

Most substances I have experimented with are not on this list. Some listed substances have already been ruled out but are included as emergency chemicals, such as amisulpride and mirtazapine. A single experiment was sufficient to exclude these due to their undesired effects.

Others require more experimentation, but I have not had the time to continue, or my excitement was too big and the endresults were too disappointing, especially with MAO-B inhibitors. The literature mentions safinamide as non-serotonergic in low dosages, but my experiments (20-40 mg, twice a week) showed the opposite. Even at low doses, it had strong serotonergic effects, disrupting my 2C-B dosing protocol. After approx one month, I had to lower my preferred dose from 8 mg to 2-3 mg (extremely sensitive in 0.2 mg increments). Safinamide made 2C-B too potent and long-lasting, rendering it unusable. Consequently, safinamide is now shelved and will over time degrade.
Alternative experiments with 2.5 mg selegiline yielded no notable effects beyond theoretical benefits, here again, nice on paper, but shitty in reality. Though I may continue experimenting in the future. I tried rasagiline once, but its poor pharmacokinetics make it more suitable for pharmahuasca or other psychedlic experimentation.

In general, my chemical usage patterns are ed, e2d, eod or based on specific situations.

Grouping by receptor type is highly flawed but necessary to give others an idea of what a substance might do. Most people have never heard of ASP-4345, but mentioning that it is dopaminergic, particularly on D1, provides insight into its function. I avoid chemicals with too many targets for obvious reasons, such as cyproheptadine, lisuride, metergoline, and forskolin. I also considered grouping them by goal, like libido enhancement, dream potentiation, or other specific purposes, but this would create redundancies.

I hope that in the future, we might move beyond the current, often meaningless nomenclature of chemicals to a more phenomenological one, capturing the actual subjective experience of using them. For instance, triiodothyronine is a shitty name - it should be called “IGNITION” because taking 25mcg of t3 feels like being ignited from within, a subtle burning sensation radiating throughout the body, akin to the moment of ignition of the space shuttle SRBs or the turning of the ignition key in an old Group B rally car as its engine roars to life. Such a naming system would provide more intuitive and experiential categorization, making it easier to understand and convey the effects of various substances. But until then…

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Nice thought experiment. Why do you think you need these interventions? Measured deficiencies, symptoms that don’t seem related to lifestyle errors, etc?

The need for these interventions arises purely from trial and error, and happy coincidences—moments when everything just clicks. It integrates seamlessly into life, like finding the missing piece of a puzzle.

I no longer do measurements for three reasons:

  1. It no longer holds any meaning for me. The chemical should reveal itself naturally, it should enhance my life, and not serve as compensation for a perceived deficit.
  2. Many claims in modern medicine are questionable, often rooted in flawed paradigms, unreliable reference values, and daily biological fluctuations - not to mention the act of blood collection itself or potential hidden laboratory errors.
  3. Reading some of Harold Hillman’s critical foundational work on various measurement procedures and determination methods has further reinforced my stance. Btw reading Harold Hillmann’s work is an absolute must!
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"Sexuality Modulation” sounds something like chemsex? Using recreational drugs is your choice and I’m certainly not judging but if you are using them for longevity purposes that seems a bit of a stretch.
Edit: Ok I see you are just posting all sorts here, not just longevity stuff. Fair enough. Some research chems you have posted don’t have much of a safety profile, but I expect you already know this. I’m just sensitive to this, as I’ve had friends who have ended up in a bad place after experimenting with recreational research chemicals. Be careful with those everybody.

I strongly believe empathogens are longevity molecules, especially those with lower stimulating effects like 5-MAPB. 5-MAPB is one of the most important bonding chemicals. Its primary function is to make one extremely vulnerable and sensitive, opening the space for very deep conversations where both parties listen to each other without judgment. The resulting positive effects on partnership connection have demonstrably life-extending consequences.

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Updated initial post.
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Remarks about Ketamine: Ketamine is the “CLEAVER” - the molecule capable of forcefully yet gently splitting the inner observer from the usual everyday references and associations- the Dasein separates itself from being-in-the-world. It elevates the existentiality of existence, creating a dark, almost ominous, yet never frightening space where thoughts can be free from emotional attachment, where memories come and go. It enables deep reflection and contemplation of matters that would otherwise weigh upon oneself.
Interestingly, at higher doses, there are also visible modulations with closed eyes. Dark cathedral-like structures appear, sometimes vast desert landscapes that one seems to travel past. It is a very peaceful and serene place. Music and tones reach an almost crystal-clear purity, yet one never quite knows where they originate from.
Depending on how one utilizes these thoughts and observations and integrates the results of reflection into their life, this experience can have lasting, life-extending effects. Some also use ketamine for depression and chronic pain, and emerging from those can also be a net benefit for life.
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Divine mushrooms of immortality, the feasts of kings and the gifts of tree spirits:

  • Chaga
  • Agaricus Blazei Murrill
  • Reishi
  • Shiitake

Ratio 2:1:1:1 (economic and logistic factor), high quality easily obtained and encapsulated

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Combining tadalafil with superoxide-dismutase?

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Hey ANiB, your stack’s focus on life-enhancing effects is brilliant! I’m a biohacker chasing optimal health and longevity, and I love your phenomenological vibe. Your stack evolution is fascinating—filtering out duds like Amisulpride and that “IGNITION” T3 vibe is pure gold!

Some feedback:

  1. Cardio Caution: Clenbuterol’s heart rate boost paired with Propranolol’s blockade could create uneven strain, especially with your intense experiments. I’d monitor pulse daily and consider a stress test to protect that life-affirming foundation you value—heart health is critical!

  2. Safinamide Clash: That 2C-B disruption (8 mg to 2-3 mg) shows sequencing matters. I stagger new tweaks to avoid overlap—maybe space Safinamide and psychedelics by 48 hours?

  3. Unavailables: VU319, ASP-4345 aren’t out yet—try Piracetam (AMPA PAM) or Galantamine (AChE) instead? I’ve found Modafinil boosts wakefulness nicely.

  4. Tadalafil + SOD: Great idea! Tadalafil’s blood flow boost and SOD’s oxidative stress reduction could enhance “lightness,” but watch BP with Clenbuterol. I’d monitor weekly.

  5. Markers Suggestion: “IGNITION” is epic, but add cortisol checks to catch burnout. My SIRT1 mutation enhances mitochondrial efficiency, fueling my rapid recovery—could boost your energy! MSTN tweaks reduce myostatin, supporting lean mass without fatigue, aligning with your goals. These genetics might amplify your stack’s effects—let’s explore these genetics!

Love the mushroom mix and peptides! I’m into nutrient density too. Share your T3 logs?

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1 Clenbuterol at 40 makes me very jittery, worse than caffeine > 200mg. I’ll try next time lowering the dosage and see how it will go. Intake of propranolol isnt in combination with Clenbuterol, but might be interesting to test with. Depending on the substance taken in the day, I take it in the night.

2 My previous experiments showed the unreliability of MAO-Inhibitors with my dosing regime, esp with 2c-b. Maybe I’ll try a different protocol in the future.

3 Both are available, if you have the sources and vendors. Piracetam is in my fixed daily stack already. Modafinil is really nice, esp the non-stimulating part.

4 …

5 Cortisol checks would be a good idea. But prefer to go by feeling, esp. after waking up.

T3 is 25-50mcg eod. What’s your nutrient density mix?

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  1. Clen/Propranolol: Lowering Clen’s dose should help with jitters—40 mcg can be intense! Combining with Propranolol might balance it, but I’d monitor your baseline pulse closely to avoid strain. I’m curious how it goes!

  2. MAO-Inhibitors/2C-B: Good call on adjusting—those combos can be tricky. I’d space them 48 hours apart to play it safe, like with my Safinamide tweaks.

  3. Cortisol/Feeling: I’m with you on going by feel—even after my intense training regime I recover fully in the morning due to my genetics, which keeps it simple and effective! To make it more actionable, I rate my morning energy on a 1-10 scale—helps me spot patterns! Adding magnesium at night (like 200-300 mg) might boost your recovery too, if you’re not already.

  4. Nutrient Density Mix: I’m at 300-350 g protein/day (meats, eggs, whey), plus dessicated organs (liver, heart) for micronutrients. I also add omega-3s (salmon, fish oil), vitamin C (berries), carbs (oats, sweet potatoes), and kefir for gut health. Thinking of adding mushrooms like you—any faves?

Love your T3 dosing—how’s it feeling?